Potassium Hydroxide → 2-(Pyridin-2-ylmethyl)imidazole

HRID 1059390노트

반응식

HRID 1059390 반응식
CN(C)S([N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1)(=O)=O.[OH-].[K+]>C(O)C>[N:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][C:7]1[NH:8][CH:9]=[CH:10][N:6]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 18670131HCID 18670131, 화합물

생성물 1

HCID 186704242-(Pyridin-2-ylmethyl)imidazole수율 42.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 0.21 g of N,N-dimethyl[2-(pyridin-2-ylmethyl)imidazol-1-yl]sulfonamide in ethanol (2 ml) was added a 2% aqueous solution (20 ml) of potassium hydroxide and the resulting mixture was heated under reflux for 11 hours. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluted with dichloromethane/methanol) to thereby give 0.053 g of the title compound as a colorless oily substance.

후처리

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 11 hours
  3. distillationAfter distilling off the solvent under reduced pressure
  4. customthe residue was purified by silica gel column chromatography (eluted with dichloromethane/methanol)

출처 및 근거

ORD 기록
ord-ef9312a1c2ec499bbd6e8cedad8f66e4
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06518423B1

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