HCID 18629909, 화합물 → HCID 18629911, 화합물
반응식
[N+:1]([C:4]1[C:9]2[N:10]=[C:11]([CH2:13][C:14]#[N:15])[O:12][C:8]=2[CH:7]=[CH:6][CH:5]=1)([O-])=O>[Pd].C1COCC1.C(O)(=O)C>[NH2:1][C:4]1[C:9]2[N:10]=[C:11]([CH2:13][C:14]#[N:15])[O:12][C:8]=2[CH:7]=[CH:6][CH:5]=1참가 물질
5
실험 절차
The mixture of 4-nitro-2-benzoxazoleacetonitrile (27.22 g, 0.13 mole) and Palladium on carbon (3 g) in THF (320 ml) and acetic acid (5 ml) in a Parr bottle was hydrogenated at 50 psi for 15 h. It was filtered over a patch of celite (1.5 cm) covered with activated carbon (0.5 cm) and washed with isopropyl ether. The filtrate was evaporated and the residue was triturated with isopropyl ether and propyl acetate and filtered to give 4-amino-2-benzoxazoleacetonitrile (14.16 g, 61%).
후처리
- filtrationIt was filtered over a patch of celite (1.5 cm)
- washwashed with isopropyl ether
- customThe filtrate was evaporated
- customthe residue was triturated with isopropyl ether and propyl acetate
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-f9109207cca944d6ba22065406ded143
- 출처 데이터셋
- uspto-grants-2003_02
- 특허 번호
- US06521397B1
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