Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → 5-Amino-2-fluoroisonicotinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 5-((tert-Butoxycarbonyl)amino)-2-fluoroisonicotinic acid | HCID 10611065 | — |
| 생성물 | 5-Amino-2-fluoroisonicotinic acid | HCID 2762511 | 75.6% |
반응 단계
Reaction of 5-[N-(tert-butoxycarbonyl)amino]-2-fluoropyridine-4-carboxylic acid (1.0 g, 3.9 mmol) with TFA as described above gives 5-amino-2-fluoropyridine-4-carboxylic acid(0.46 g, 74%). 1H NMR (DMSO) δ 7.85 (1H, d, J=1.5 Hz), 7.23 (1H, d, J=2.5 Hz).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06521620B1 |
| 출처 데이터셋 | uspto-grants-2003_02 |
| ORD ID | ord-4fe7263a8326468697b13918a4e760e8 |
| 출처 메모 | uspto-grants-2003_02 |