Potassium Bromide → HCID 12044122, 화합물

HRID 1059697노트

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HRID 1059697 반응식
[NH2:1][C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=O.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH2:22][CH2:23][N:24]([CH2:27][CH2:28][CH2:29][NH2:30])[CH2:25][CH:26]=2)=[CH:17][CH:16]=1.CC1C=CC=C2C=1N[C:39](=[O:42])NC2=O.[K+].[Br-]>>[Cl:13][C:10]1[C:11]([CH3:12])=[C:2]2[C:3]([C:4](=[O:6])[N:30]([CH2:29][CH2:28][CH2:27][N:24]3[CH2:23][CH:22]=[C:21]([C:18]4[CH:19]=[CH:20][C:15]([Cl:14])=[CH:16][CH:17]=4)[CH2:26][CH2:25]3)[C:39](=[O:42])[NH:1]2)=[CH:8][CH:9]=1

참가 물질

5

반응물 4

HCID 253877Potassium BromideHCID 3340238-Methylquinazoline-2,4(1H,3H)-dioneHCID 11276773HCID 11276773, 화합물HCID 14155405Benzoic acid, 2-amino-4-chloro-3-methyl-, methyl ester

생성물 1

HCID 12044122HCID 12044122, 화합물

실험 절차

The same general procedure was followed as in Example 7 with starting materials, 2-amino-3-methyl-4-chloro-benzoic acid, methyl ester and 3-[4-(4-Chloro-phenyl)-3,6-dihyro-2H-pyridin-1-yl]-propylamine to yield 7-Chloro-3-{3-[4-(4-chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl{-8-methyl-1H-quinazoline-2,4-dione. The maleate salt of the compound has the following was found to have: Mp. 208-210° C.; 1H NMR DMSO-d6 δ 10.90 (s, 1H), 9.44 (brd s, 1H), 7.80 (d, J=8.7 Hz, 1H), 7.46 (dd, J=8.7, 20.5 Hz, 4H) 7.28 (d, J=8.5 Hz, 1H), 6.20 (brd s, 1H), 6.00 (s, 2H), 3.98 (t, J=6.4 Hz, 2H), 3.84-3.54 (m, 2H), 3.38-3.26 (m, 2H), 3.25-3.10 (m, 2H), 2.75-2.624(m, 2H), 2.39 (s, 3H), 2.10-1.99 (m, 2H); IR (KBr) 3351, 3226, 3071 2965, 2728, 2603, 1904, 1714, 1656, 1612, 1596, 1448, 1353, 1321, 1294, 1261, 1205, 1152, 1134, 1094, 1011, 989, 950, 922, 866, 836, 811, 763, 729, 706, 682, 645, 579, 523, 511, 499, 468, 441, 404; Analysis calculated for C23H23Cl2N3O2.C4H4O4: C, 57.86; H, 4.86; N, 7.50. Found: C, 57.55; H, 4.79; N, 67.36.

후처리

  1. customto yield 7-Chloro-3-{3-[4-(4-chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-propyl

출처 및 근거

ORD 기록
ord-3898672e0ac74f719ffe7385d790e249
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06521630B1

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