3-(4-Methylpyridin-2-yl)nitrobenzene → 2-(3-Aminophenyl)-4-methylpyridine

HRID 1059924노트

반응식

HRID 1059924 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:9]=[C:10]([N+:14]([O-])=O)[CH:11]=[CH:12][CH:13]=2)[CH:3]=1>C(O)C.[Pd]>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=2)[NH2:14])[CH:3]=1

참가 물질

4

반응물 1

HCID 128111223-(4-Methylpyridin-2-yl)nitrobenzene

생성물 1

HCID 186676162-(3-Aminophenyl)-4-methylpyridine수율 98.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A suspension of 3-(4-methylpyridin-2-yl)nitrobenzene (100 mg) in ethanol (2 ml) was hydrogenated over palladium on carbon (10% w/w, 50% wet, 10 mg) under a hydrogen atmosphere for 3 hours. The catalyst was filtered off, and the filtrate was evaporated under reduced pressure to give 3-(4-methylpyridin-2-yl)aniline (85 mg).

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-208ecb5c84814deb92796c10a9b41c0a
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06521643B1

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