4-(4-Methoxypyridin-2-yl)-2-nitrotoluene → 5-(4-Methoxypyridin-2-yl)-2-methylaniline

HRID 1059975노트

반응식

HRID 1059975 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([N+:16]([O-])=O)[CH:10]=2)[CH:4]=1>O1CCCC1.C(O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[C:11]([CH:10]=2)[NH2:16])[CH:4]=1

참가 물질

5

반응물 1

HCID 186310034-(4-Methoxypyridin-2-yl)-2-nitrotoluene

생성물 1

HCID 186676385-(4-Methoxypyridin-2-yl)-2-methylaniline수율 96.5%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

A suspension of 4-(4-methoxypyridin-2-yl)-2-nitrotoluene (300 mg) in tetrahydrofuran (3 ml) and ethanol (3 ml) was hydrogenated over palladium on carbon (10% w/w, 50% wet, 150 mg) under a hydrogen atmosphere for 3 hours. The catalyst was filtered off, and the filtrate was evaporated under reduced pressure to give 5-(4-methoxypyridin-2-yl)-2-methylaniline (254 mg).

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-6ba881de2be0410e8f67d1743402cb68
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06521643B1

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