4-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazole → Methyl 5-(5-methyl-2-phenyl-4-oxazolylmethoxy)bezofuran-2-carboxylate

HRID 1060

반응식

HRID 1060 반응식
[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]([O:12][CH3:13])=[O:11])=[CH:7][C:6]=2[CH:14]=1.Cl[CH2:16][C:17]1[N:18]=[C:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[O:20][C:21]=1[CH3:22]>>[CH3:22][C:21]1[O:20][C:19]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)=[N:18][C:17]=1[CH2:16][O:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]([O:12][CH3:13])=[O:11])=[CH:7][C:6]=2[CH:14]=1

참가 물질

3

반응물 2

HCID 97942894-(Chloromethyl)-5-methyl-2-phenyl-1,3-oxazoleHCID 12208973Methyl 5-hydroxybenzofuran-2-carboxylate

생성물 1

HCID 70290035Methyl 5-(5-methyl-2-phenyl-4-oxazolylmethoxy)bezofuran-2-carboxylate수율 87%

실험 절차

In the same manner as in Reference Example 4, methyl 5-hydroxybenzofuran-2-carboxylate was reacted with 4-chloromethyl-5-methyl-2-phenyloxazole to yield methyl 5-(5-methyl-2-phenyl-4-oxazolylmethoxy)bezofuran-2-carboxylate (yield 87%), which was then recrystallized from acetone-ethyl acetate to yield colorless prisms having a melting point of 177° to 178° C.

출처 및 근거

ORD 기록
ord-b3116d4c51654c129518e27f86a5d786
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723479

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