Chlorotrimethylsilane → HCID 18630201, 화합물

반응식

[CH2:1]([NH:3][C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:2].[CH3:12][Si:13](Cl)([CH3:15])[CH3:14]>>[CH2:1]([NH:3][C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Si:13]([CH3:15])([CH3:14])[CH3:12])[CH3:2]

참가 물질

반응물 2

HCID 6397Chlorotrimethylsilane

HCID 11959N-Ethylbenzamide

생성물 1

HCID 18630201HCID 18630201, 화합물수율 68.3%

실험 절차

N-Ethylbenzamide (74.5 g, 500 mmol) and TMSCl (135.8 g, 1.25 mol) were combined according to General Method C and purified by HPLC with 1:4 ethyl acetate/hexanes to afford 75.59 g of the title compound, as a white solid, a 68% yield. m.p. 64.0-66.0° C.

후처리

custompurified by HPLC with 1:4 ethyl acetate/hexanes

출처 및 근거

ORD 기록: ord-3b4c0cd6d3f54e84b4f0bbe596b83d78
출처 데이터셋: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06521603B2

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