HCID 178488787, 화합물 → HCID 178488788, 화합물
반응식
C(OC([NH:8][C:9]1[NH:10][CH:11]=[C:12]([C:14]2[C:22]3[S:21][C:20]([NH:23][C:24](=[O:26])[OH:25])=[N:19][C:18]=3[C:17]([O:27][CH3:28])=[CH:16][CH:15]=2)[N:13]=1)=O)(C)(C)C>Cl.CO>[NH2:8][C:9]1[NH:10][CH:11]=[C:12]([C:14]2[C:22]3[S:21][C:20]([NH:23][C:24](=[O:25])[OH:26])=[N:19][C:18]=3[C:17]([O:27][CH3:28])=[CH:16][CH:15]=2)[N:13]=1참가 물질
3
실험 절차
0.04 g of [7-(2-tert-butoxycarbonylamino-1H-imidazol-4-yl)-4-methoxy-benzothiazol-2-yl]-carbamic acid methyll ester (0.0001 Mol) were heated to 60° C. in HCl/MeOH (2.5 M, 2 ml). After evaporation of the solvent the residue was dissolved in water (5 ml) and the pH was adjusted to 8 with sat. NaHCO3. The water was evaporated and the residue triturated in ethyl acetate where a precipitation formed. This was isolated and dried to yield the title compound as a grey solid (16%); F.p.: 225-235° C.
후처리
- customAfter evaporation of the solvent the residue
- dissolution