Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1060426생성일: 2026년 10월 26일
Methyl isothiocyanate → N-[2-chloro-4-(3-methylthioureido)benzoyl]-4-(2-methoxyphenyl)-L-phenylalanine methyl ester
https://huagongshe.com/reaction/1060426
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl isothiocyanate | HCID 11167 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | N-(4-amino-2-chlorobenzoyl)-4-(2-methoxyphenyl)-L-phenylalanine methyl ester | HCID 54392214 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-[2-chloro-4-(3-methylthioureido)benzoyl]-4-(2-methoxyphenyl)-L-phenylalanine methyl ester | HCID 54405488 | — |
반응 단계
Methylisothiocyanate (43 μL) was added to a solution of N-(4-amino-2-chlorobenzoyl)-4-(2-methoxyphenyl)-L-phenylalanine methyl ester (55.1 mg) in anhydrous DMF (1 mL) containing DIEA (22 μL) and DMAP (catalitic amount). The resulting mixture was then heated at 90° C. under N2 for 1 d. After cooling, the mixture was diluted with EtOAc, washed sequentially with 1N HCl, satd. NaHCO3 and water, dried (MgSO4) and evaporated. The residue was purified by preparative TLC (silica gel) using CH2Cl2/MeOH (15:1) as an eluent to give N-[2-chloro-4-(3-methylthioureido)benzoyl]-4-(2-methoxyphenyl)-L-phenylalanine methyl ester (22.7 mg). ESMS: m/z 512 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06521666B1 |
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| 출처 데이터셋 | uspto-grants-2003_02 |
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| ORD ID | ord-358f1c936d364d5e8ed4ccaf1863b67c |
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| 출처 메모 | uspto-grants-2003_02 |
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