Potassium Hydroxide → Sodium 4-(6-hydroxyhexyl)oxybenzenesulfonate

HRID 10605노트

반응식

HRID 10605 반응식
[Na+:1].[OH:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([O-:12])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[OH-].[K+].Br[CH:16]([OH:22])[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]>C(O)C>[OH:22][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([O-:12])(=[O:10])=[O:11])=[CH:5][CH:4]=1.[Na+:1]

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 4379756Sodium 4-hydroxybenzenesulfonateHCID 21981760Bromohexanol

생성물 1

HCID 23717227Sodium 4-(6-hydroxyhexyl)oxybenzenesulfonate수율 98.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Into a three-necked round-bottom flask equipped with a magnetic stirring bar and a reflux condenser were added 4-hydroxybenzenesulfonicacid sodium salt (30.0 grams (g), 0.13 mol), potassium hydroxide (9.0 g, 0.16 mol) and distilled water (60 milliliter (ml)). 1-Bromohexanol (23.16 g, 0.13 mol) dissolved in ethanol (50 ml) was added drop wise into the reaction mixture at room temperature. The reaction mixture was refluxed for 24 hours and then cooled to room temperature. The precipitated product was filtered and washed with chloroform to remove excess of 1-bromohexanol. The product was dried under vacuum at 70° C. for 12 hours to provide 38.06 g of sodium 4-(6-hydroxyhexyl)oxybenzenesulfonate (92% yield).

후처리

  1. customInto a three-necked round-bottom flask equipped with a magnetic stirring bar and a reflux condenser
  2. distillationdistilled water (60 milliliter (ml))
  3. additionwas added drop wise into the reaction mixture at room temperature
  4. temperatureThe reaction mixture was refluxed for 24 hours
  5. filtrationThe precipitated product was filtered
  6. washwashed with chloroform
  7. customto remove excess of 1-bromohexanol
  8. customThe product was dried under vacuum at 70° C. for 12 hours

출처 및 근거

ORD 기록
ord-62574a4f57594484b87becc8b7f760e8
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094861B2

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