참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 2-Formyl-4,5-dimethoxybenzoic acid | HCID 7176207 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
반응 단계
A suspension of 2-formyl-4,5-dimethoxy-benzoic acid (6.43 g, 30.62 mmoles), obtained as described in example 2, triphenyl-phosphine (8.3 g, 30.62 mmoles), 30% HBr in acetic acid (8.26 ml, 30.62 mmoles) and glacial acetic acid (20 ml) under N2 was heated at 90° C. for 4.5 hours. The mixture was brought to dryness, re-dissolved in acetonitrile (50 ml) and diluted with ethyl ether up to turbidity, then cooled and filtered, and the filtrate was washed with ethyl ether and dried under vacuum to give 13.6 g of the title compound (yield: 83%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06525055B1 |
|---|
| 출처 데이터셋 | uspto-grants-2003_02 |
|---|
| ORD ID | ord-cbbf3575b47045bca0481a74c07a90ae |
|---|
| 출처 메모 | uspto-grants-2003_02 |
|---|
