Potassium Hydroxide → 5-Bromo-7-chloroindoline

HRID 1060622노트

반응식

HRID 1060622 반응식
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([Br:14])=[CH:10][C:11]=2[Cl:13])[CH2:6][CH2:5]1)(=O)C.[OH-].[K+]>C(O)C.O>[Br:14][C:9]1[CH:8]=[C:7]2[C:12](=[C:11]([Cl:13])[CH:10]=1)[NH:4][CH2:5][CH2:6]2

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 186292691-(5-Bromo-7-chloro-2,3-dihydro-1H-indol-1-yl)ethan-1-one

생성물 1

HCID 167891645-Bromo-7-chloroindoline수율 87.8%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Part B: 1-acetyl-5-bromo-7-chloroindoline (1.17 g) was dissolved in a mixture of ethanol (15 mL) and water (8 mL) containing KOH (0.5 g) and heated to reflux for 2 h. The reaction was partitioned between EtOAc (100 mL) and water (20 mL). The organic extract was washed with brine (20 mL), dried and stripped in vacuo to give 5-bromo-7-chloroindoline (0.87 g).

후처리

  1. temperatureheated
  2. temperatureto reflux for 2 h
  3. customThe reaction was partitioned between EtOAc (100 mL) and water (20 mL)
  4. extractionThe organic extract
  5. washwas washed with brine (20 mL)
  6. customdried

출처 및 근거

ORD 기록
ord-8ee73df8cb29452c817807b2032d3d5d
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06525056B2

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