1-Methyl-5-(4-nitrophenyl)-1H-tetrazole → 4-(1-methyl-1H-1,2,3,4-tetrazol-5-yl)aniline

HRID 1060726노트

반응식

HRID 1060726 반응식
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=2)=[N:5][N:4]=[N:3]1>[OH-].[OH-].[Pd+2].CO.CCOC(C)=O>[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=2)=[N:5][N:4]=[N:3]1

참가 물질

4

반응물 1

HCID 126725461-Methyl-5-(4-nitrophenyl)-1H-tetrazole

생성물 1

HCID 222590184-(1-methyl-1H-1,2,3,4-tetrazol-5-yl)aniline수율 95.4%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 21584119Ethylacetate methanol용매

실험 절차

1-Methyl-5-(4-nitro-phenyl)-1H-tetrazole (470 mg), 20% Pd(OH)2 (94 mg), and 1:1 MeOH/EtOAc (25 ml), were hydrogenated at 50 PSI for 1 hour. The reaction was filtered through fiberglass filter paper under nitrogen. The filtrate was stripped to yield 383 mg of yellow solids as product. Mass Spec detects 176 (M+H). NMR (300 MHz, CDCl3) δ 7.57 (d, 2H, J=7 Hz), 6.80 (d, 2H, J=7 Hz), 4.14 (s, 3H), 4.03 (M, 2H).

후처리

  1. filtrationThe reaction was filtered through fiberglass
  2. filtrationfilter paper under nitrogen

출처 및 근거

ORD 기록
ord-e766c2b5e2ec4984871458534635c44e
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06525069B1

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