Sodium Iodide → HCID 18629502, 화합물
반응식
[C:1](=[O:14])([O:5][CH2:6][C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[O:2][CH2:3]Cl.[I-:15].[Na+]>C(#N)C>[C:1](=[O:14])([O:5][CH2:6][C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[O:2][CH2:3][I:15]참가 물질
4
반응 조건
- 온도
- 40 °C
실험 절차
Chloromethyl tert-butoxycarbonylmethyl carbonate (6.45 g) was added to a solution of sodium iodide (16.5 g) in acetonitril (65 ml). After stirring at 40° C. for 4 hours the reaction mixture was cooled in ice, filtered and evaporated in vacuo. The residue was taken up in dichloromethane, washed with aqueous sodium bicarbonate and sodium thiosulfate, dried over magnesium sulfate, filtered and evaporated in vacuo. Purification on silica gel with hexane/ethyl acetate (3:1) as eluent gave the title compound as a colourless oil.
후처리
- temperaturewas cooled in ice
- filtrationfiltered
- customevaporated in vacuo
- washwashed with aqueous sodium bicarbonate and sodium thiosulfate
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- customevaporated in vacuo
- customPurification on silica gel with hexane/ethyl acetate (3:1) as eluent
출처 및 근거
- ORD 기록
- ord-ff36d2dd32054077ac5a844b06e75a2f
- 출처 데이터셋
- uspto-grants-2003_02
- 특허 번호
- US06525077B2
반응 노트
불러오는 중…