3-(3-Methoxy-benzenesulfonylamino)-propionic acid → N-(3-hydroxy-propyl)-3-methoxy-benzenesulfonamide

HRID 1060894노트

반응식

HRID 1060894 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9]([NH:12][CH2:13][CH2:14][C:15](O)=[O:16])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1>C1COCC1>[OH:16][CH2:15][CH2:14][CH2:13][NH:12][S:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=1)(=[O:11])=[O:10]

참가 물질

3

반응물 1

HCID 186294403-(3-Methoxy-benzenesulfonylamino)-propionic acid

생성물 1

HCID 18629442N-(3-hydroxy-propyl)-3-methoxy-benzenesulfonamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

3-(3-Methoxy-benzenesulfonylamino)-propionic acid (0.755 g, 2.91 mmol), was dissolved in THF (10 mL), cooled in an ice-H2O bath, and treated with borane THF complex (3.49 mL of a 1M solution, 3.49 mmol) with stirring. After warming to room temperature over 1 h, the reaction was cooled in an ice bath, and quenched by dropwise addition of H2O, then partitioned between H2O and CH2Cl2. The aqueous layer was washed with CH2Cl2 (3×20 mL), dried (MgSO4). Filtration and concentration in vacuo gave the title compound which was used without further purification.

후처리

  1. temperaturecooled in an ice-H2O bath
  2. temperaturethe reaction was cooled in an ice bath
  3. customquenched by dropwise addition of H2O
  4. custompartitioned between H2O and CH2Cl2
  5. washThe aqueous layer was washed with CH2Cl2 (3×20 mL)
  6. dry with materialdried (MgSO4)
  7. filtrationFiltration and concentration in vacuo

출처 및 근거

ORD 기록
ord-a79f9991b4fe44e892010678ab2e9673
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06525074B2

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