Acetone → HCID 22711430, 화합물

HRID 1061008노트

반응식

HRID 1061008 반응식
Cl.C(O)C.CC(C)=O.C(OC([N:16]1[CH2:21][CH2:20][N:19]([C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N+:31]=3[O-:36])=[CH:26][CH:25]=2)=[O:23])[CH2:18][CH2:17]1)=O)(C)(C)C>ClCCl>[N:19]1([C:22]([C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N+:31]=3[O-:36])=[CH:26][CH:25]=2)=[O:23])[CH2:20][CH2:21][NH:16][CH2:17][CH2:18]1

참가 물질

5

반응물 3

HCID 180AcetoneHCID 21887872Ethanol hydrochlorideHCID 69700183HCID 69700183, 화합물

생성물 1

HCID 22711430HCID 22711430, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In dichloromethane (2.5 ml), 2-[4-[[4-(tert-butoxycarbonyl)piperazin-1-yl]carbonyl]phenyl]pyridine N-oxide was dissolved. To the resulting solution, a saturated solution of ethanol hydrochloride (2.5 ml) was added, followed by stirring at room temperature for 1 hour. After the solvent was distilled off under reduced pressure, water was added to the residue, whereby an aqueous solution was obtained. Acetone was added to the aqueous solution until the solution became turbid. The precipitate was collected by filtration and washed with acetone, whereby the title compound (274 mg, 81%) was obtained.

후처리

  1. distillationAfter the solvent was distilled off under reduced pressure, water
  2. additionwas added to the residue, whereby an aqueous solution
  3. customwas obtained
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with acetone, whereby the title compound (274 mg, 81%)
  6. customwas obtained

출처 및 근거

ORD 기록
ord-b5f09648e6234f70b2646c5849bad27f
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06525042B1

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