HCID 178418287, 화합물 → HCID 178453606, 화합물

HRID 1061013노트

반응식

HRID 1061013 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([CH2:16][OH:17])[CH2:12][CH2:11]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>ClCCl>[C:1]([O:5][C:6]([NH:8][CH2:9][C@H:10]1[CH2:11][CH2:12][C@H:13]([CH:16]=[O:17])[CH2:14][CH2:15]1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

참가 물질

4

반응물 2

HCID 178418287HCID 178418287, 화합물HCID 178453607HCID 178453607, 화합물

생성물 1

HCID 178453606HCID 178453606, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In dichloromethane (5 ml), trans-4-(N-tert-butoxycarbonylaminomethyl)cyclohexylmethanol (0.20 g) was dissolved, followed by the addition of pyridinium chlorochromate (0.23 g). The resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was purified by chromatography on a silica gel column (hexane:ethyl acetate=3:1), whereby the title compound (0.15 g, 76%) was obtained.

후처리

  1. customThe reaction mixture was purified by chromatography on a silica gel column (hexane:ethyl acetate=3:1), whereby the title compound (0.15 g, 76%)
  2. customwas obtained

출처 및 근거

ORD 기록
ord-de0b05833a0844ddb2c6e5db8c6cc962
출처 데이터셋
uspto-grants-2003_02
특허 번호
US06525042B1

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