Ammonia → (2RS,3S)-3-Amino-2-hydroxy-4-phenylbutyramide

HRID 1061655노트

반응식

HRID 1061655 반응식
[NH2:1][C@@H:2]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:3]([OH:10])[C:4](OC(C)C)=[O:5].[NH3:18]>CO>[NH2:1][C@@H:2]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:3]([OH:10])[C:4]([NH2:18])=[O:5]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 11736536isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate

생성물 1

HCID 57310726(2RS,3S)-3-Amino-2-hydroxy-4-phenylbutyramide

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of isopropyl (2RS,3S)-3-amino-2-hydroxy-4-phenylbutyrate (200 mg, Reference compound No. 4-1) in methanol (3 ml) is saturated with an ammonia gas, and the solution is sealed and stirred overnight. The reaction solution is concentrated under reduced pressure to give the titled reference compound (162 mg).

후처리

  1. customthe solution is sealed
  2. concentrationThe reaction solution is concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8aa7d5ce399044a19095ca39e8c1e607
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06960575B2

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