HCID 22285265, 화합물 → HCID 10109623, 화합물

HRID 1061752노트

반응식

HRID 1061752 반응식
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([C:12]([F:15])([F:14])[F:13])=[N:7]2.[F:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][C:18]=1[C:26]1[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=1>>[F:16][C:17]1[CH:22]=[CH:21][C:20]([C:2]2[CH:11]=[CH:10][N:9]=[C:8]3[C:3]=2[CH:4]=[CH:5][C:6]([C:12]([F:15])([F:14])[F:13])=[N:7]3)=[CH:19][C:18]=1[C:26]1[CH:27]=[CH:28][N:29]=[CH:30][CH:31]=1

참가 물질

3

반응물 2

HCID 22285265HCID 22285265, 화합물HCID 222852765-chloro-2-(trifluoromethyl)-1,8-Naphthyridine

생성물 1

HCID 10109623HCID 10109623, 화합물수율 55.4%

실험 절차

5-Chloro-2-trifluoromethyl[1,8]naphthyridine (100 mg, 0.43 mmol) was coupled to 4-fluoro-3-(pyridin-4-yl)benzeneboronic acid (121 mg, 0.56 mmol) as described in Example 3 part g), affording 5-(4-fluoro-3-pyridin-4-ylphenyl)-2-trifluoromethyl[1,8]naphthyridine (88 mg, 55%). δH (360 MHz, CDCl3) 7.41-7.47 (1H, m), 7.52-7.63 (5H, m), 7.85 (1H, d, J 8.8), 8.52 (1H, d, J 8.4), 8.73-8.74 (2H, m), 9.30 (1H, d, J 4.2). m/z (ES+) 370 [MH]+.

출처 및 근거

ORD 기록
ord-016c9546e73e4a23a57269c59e1d1b9a
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06960598B2

반응 노트

불러오는 중…