N-(3-Nitro[1,1'-biphenyl]-4-yl)carbamic Acid tert-Butyl Ester → N-(3-Amino[1,1'-biphenyl]-4-yl)-carbamic Acid tert-Butyl Ester

HRID 1061957

반응식

HRID 1061957 반응식
[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:10][C:9]=1[N+:20]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:10][C:9]=1[NH2:20])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 1

HCID 57745588N-(3-Nitro[1,1'-biphenyl]-4-yl)carbamic Acid tert-Butyl Ester

생성물 1

HCID 57717454N-(3-Amino[1,1'-biphenyl]-4-yl)-carbamic Acid tert-Butyl Ester수율 93.4%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

Prepared from (3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example B5) (100 mg, 0.32 mmol) by catalytic hydrogenation with Pd/C according to the general procedure G (method a). Obtained as a white solid (85 mg).

출처 및 근거

ORD 기록
ord-3e814e34926a42be833a3e1023cf4054
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06960578B2

연결된 노트

불러오는 중…