Ethyl 3-oxo-3-(thiophen-3-yl)propanoate → [3-(3-Oxo-3-thiophen-3-yl-propionylamino)-biphenyl-4-yl]-carbamic acid tert.-butyl ester

HRID 1062046

반응식

HRID 1062046 반응식
[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:10][C:9]=1[NH2:20])([CH3:4])([CH3:3])[CH3:2].C([O:24][C:25](=O)[CH2:26][C:27](=[O:33])[C:28]1[CH:32]=[CH:31][S:30][CH:29]=1)C>>[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:10][C:9]=1[NH:20][C:25](=[O:24])[CH2:26][C:27](=[O:33])[C:28]1[CH:32]=[CH:31][S:30][CH:29]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 10535956Ethyl 3-oxo-3-(thiophen-3-yl)propanoateHCID 57717454N-(3-Amino[1,1'-biphenyl]-4-yl)-carbamic Acid tert-Butyl Ester

생성물 1

HCID 86588003[3-(3-Oxo-3-thiophen-3-yl-propionylamino)-biphenyl-4-yl]-carbamic acid tert.-butyl ester수율 81.3%

실험 절차

Prepared from (3-amino-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G9) (144 mg, 0.51 mmol) and 3-oxo-3-thiophen-3-yl-propionic acid ethyl ester (FR 7191887) (151 mg, 0.76 mmol) according to the general procedure K. Obtained as a yellow foam (181 mg).

출처 및 근거

ORD 기록
ord-94c8b5f61ffc401ca113931d8ec0fea4
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06960578B2

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