Trifluoroacetic acid → 8-Iodo-4-thiophen-2-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one
반응식
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([I:14])=[CH:10][C:9]=1[NH2:15])(C)(C)C.CC1(C)O[C:22](=[O:24])[CH:21]=[C:20]([C:25]2[S:26][CH:27]=[CH:28][CH:29]=2)O1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[I:14][C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[C:20]([C:25]3[S:26][CH:27]=[CH:28][CH:29]=3)[CH2:21][C:22](=[O:24])[NH:15][C:9]=2[CH:10]=1참가 물질
5
실험 절차
Prepared from (2-amino-4-iodo-phenyl)-carbamic acid tert.-butyl ester (Example G1) and 2,2-dimethyl-6-thiophen-2-yl-[1,3]dioxin-4-one (Example J1) according to the general procedure K. The obtained material was deprotected and cyclized by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a yellow solid (30 mg).
출처 및 근거
- ORD 기록
- ord-fc208c932b354c4395138ece585b3e9a
- 출처 데이터셋
- uspto-grants-2005_11
- 특허 번호
- US06960578B2
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