Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-bromobutanimide → 5-bromo-2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazole-4-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazole-4-carboxylic acid | HCID 21868804 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-bromo-2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazole-4-carboxylic acid | HCID 21868793 | 50% |
반응 단계
A solution of 2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazole-4-carboxylic acid (50 mg, 0.15 mmol) and N-bromosuccinimide (88 mg, 0.49 mmol) in dimethylformamide (5 mL) was stirred at 75° C. for 3 days. The solution was purified by preparative HPLC to give 5-bromo-2-(2-chlorophenyl)-1-(4-chlorophenyl)-1H-imidazole-4-carboxylic acid as a white solid (30.7 mg, 50%). LC-MS m/z 411.2 (MH+), retention time 2.70 min (method 2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06960601B2 |
| 출처 데이터셋 | uspto-grants-2005_11 |
| ORD ID | ord-e31f3f6d1a5843f1a87dfba21551d645 |
| 출처 메모 | uspto-grants-2005_11 |