Chlorosulfonic acid → HCID 22285655, 화합물
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]=[C:14]([Cl:25])[C:15]=1[O:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1)[CH2:5][CH:6]1[S:10][C:9](=[O:11])[NH:8][C:7]1=[O:12].[Cl:26][S:27](O)(=[O:29])=[O:28]>>[Cl:25][C:14]1[CH:13]=[C:4]([CH2:5][CH:6]2[S:10][C:9](=[O:11])[NH:8][C:7]2=[O:12])[CH:3]=[C:2]([Cl:1])[C:15]=1[O:16][C:17]1[CH:18]=[CH:19][C:20]([O:23][CH3:24])=[C:21]([S:27]([Cl:26])(=[O:29])=[O:28])[CH:22]=1참가 물질
3
실험 절차
The title compound of Step D (52 mg, 0.13 mmol) was cooled to 0° C. and chlorosulfonic acid (0.5 mL) was added. The mixture was warmed to room temperature and stirred for about 1.5 hours. The solution was poured into ice (75 g), stirred until the ice had melted, and then extracted with ethyl acetate (3×25 ml). The combined extracts were washed with brine, dried over sodium sulfate, filtered and concentrated to afford the title compound (38.0 mg) as a brownish solid which was used in the next step without purification.
후처리
- extractionextracted with ethyl acetate (3×25 ml)
- washThe combined extracts were washed with brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated