Water → HCID 11315915, 화합물

HRID 1062623노트

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HRID 1062623 반응식
[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:19])[CH2:12][C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[Br:20]Br.O>C(O)(=O)C>[BrH:20].[Br:20][CH:12]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)[C:11]([C:8]1[CH:9]=[CH:10][C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])=[CH:6][CH:7]=1)=[O:19]

참가 물질

5

반응물 3

HCID 962WaterHCID 24408BromineHCID 104674521-[4-(1,1-DIMETHYLETHYL)PHENYL]-2-(4-PYRIDYL)ETHANONE

생성물 1

HCID 11315915HCID 11315915, 화합물수율 119.2%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
80 °C

실험 절차

1-[4-(1,1-Dimethylethyl)phenyl]-2-(4-pyridyl)ethanone (10 g, 39 mmol) was dissolved in acetic acid (40 mL) and bromine (2.0 mL, 39 mmol) was added. The mixture was stirred at 80° C. for 3 h. The reaction mixture was cooled with iced water and the precipitated crude crystals were collected by filtration. The crude crystals were washed with ethyl acetate to give the title compound (9.6 g, yield 81%).

후처리

  1. customthe precipitated crude crystals
  2. filtrationwere collected by filtration
  3. washThe crude crystals were washed with ethyl acetate

출처 및 근거

ORD 기록
ord-f4bd80bc9c6b4b319f78dc9c59c4b919
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06962933B1

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