Ethyl Acetate → 2-Bromo-1-(3,5-dimethylphenyl)-2-(4-pyridyl)ethanone hydrocbromide

HRID 1062624노트

반응식

HRID 1062624 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.[Br:18]Br.C(OCC)(=O)C>C(O)(=O)C>[BrH:18].[Br:18][CH:10]([C:11]1[CH:12]=[CH:13][N:14]=[CH:15][CH:16]=1)[C:9]([C:4]1[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([CH3:1])[CH:3]=1)=[O:17]

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 24408BromineHCID 222822971-(3,5-Dimethylphenyl)-2-(4-pyridyl)ethanone

생성물 1

HCID 222823612-Bromo-1-(3,5-dimethylphenyl)-2-(4-pyridyl)ethanone hydrocbromide수율 268.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
80 °C

실험 절차

1-(3,5-Dimethylphenyl)-2-(4-pyridyl)ethanone (7.0 g, 31 mmol) was dissolved in acetic acid (35 mL) and bromine (1.6 mL, 31 mmol) was added. The mixture was stirred at 80° C. for 3 h. Ethyl acetate was added to the residue and the precipitated crude crystals were collected by filtration. The crude crystals were washed with ethyl acetate to give the title compound (16 g, yield 96%).

후처리

  1. customthe precipitated crude crystals
  2. filtrationwere collected by filtration
  3. washThe crude crystals were washed with ethyl acetate

출처 및 근거

ORD 기록
ord-6f7af2f2688c4bf982c5924a2bc5786b
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06962933B1

반응 노트

불러오는 중…