Sodium Bicarbonate → HCID 22282317, 화합물

HRID 1062649

반응식

HRID 1062649 반응식
Br.Br[CH:3]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)[C:4]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=O.C[C:20]1[CH:28]=[CH:27][C:23]([C:24]([NH2:26])=[S:25])=[CH:22][CH:21]=1.C(=O)([O-])O.[Na+]>CN(C)C=O>[F:12][C:9]1[CH:10]=[CH:11][C:6]([C:4]2[N:26]=[C:24]([C:23]3[CH:27]=[CH:28][CH:20]=[CH:21][CH:22]=3)[S:25][C:3]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 7372094-MethylbenzenecarbothioamideHCID 11164724HCID 11164724, 화합물

생성물 1

HCID 22282317HCID 22282317, 화합물수율 19.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 2-bromo-1-(4-fluorophenyl)-2-(4-pyridyl)ethanone hydrobromide (1.6 g, 4.1 mmol) and thiobenzamide (0.57 g, 4.2 mmol) in N,N-dimethylformamide (5 mL) was stirred at room temperature for 14 h. To the reaction mixture was poured aqueous sodium hydrogencarbonate solution and the precipitated solid was collected by filtration. The obtained solid was washed with water and dried. The crude crystals were recrystallized from ethyl acetate to give the title compound (0.27 g, yield 19%).

후처리

  1. filtrationthe precipitated solid was collected by filtration
  2. washThe obtained solid was washed with water
  3. customdried
  4. customThe crude crystals were recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-f7dda7cc1d4043bb968d24d953958261
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06962933B1

연결된 노트

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