Acetic Acid → 4-Methoxy-1H-pyrazolo[3,4-d]pyrimidin-6-amine
반응식
Cl[C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]2[NH:9][N:10]=[CH:11][C:3]=12.[C:12](O)(=[O:14])C>C[O-].[Na+]>[CH3:12][O:14][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]2[NH:9][N:10]=[CH:11][C:3]=12참가 물질
4
실험 절차
Compound 3 (70.4 g, 0.416 mol) was refluxed in methanolic sodium methoxide solution (25 g sodium dissolved in 1 L methanol) for 2 h. The reaction mixture was cooled to room temperature and neutralized by addition of acetic acid (75 ml). The mixture was evaporated to dryness and the solid was triturated in 600 ml of water, filtered and dried to provide 67.5 g (99% yield) of 4-methoxy-6-aminopyrazolo[3,4-d]pyrimidine (4).
후처리
- customThe mixture was evaporated to dryness
- customthe solid was triturated in 600 ml of water
- filtrationfiltered
- customdried
출처 및 근거
- ORD 기록
- ord-3142ad87d75e4854845801b740436dbc
- 출처 데이터셋
- uspto-grants-2005_11
- 특허 번호
- US06962991B2
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