Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine chloride → 5-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-iodo-benzothiazol-2-yl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine chloride | HCID 24640 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | (4-Methoxy-benzothiazol-2-yl)-carbamic acid methyl ester | HCID 21303403 | — |
| 반응물 | 5-Methyl-thiophene-2-carboxylic acid (4-methoxy-benzothiazol-2-yl)-amide | HCID 36001214 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 5-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-iodo-benzothiazol-2-yl)-amide | HCID 86584906 | 93% |
반응 단계
Iodination of 5-methyl-thiophene-2-carboxylic acid (4-methoxy-benzothiazol-2-yl)-amide (5.17 g, 17 mmol) with iodine monochloride (2.26 ml, 44 mmol), sodium acetate (3.63 g, 44 mmol) and acetic acid (200 ml) in the same manner as described for (4-methoxy-benzothiazol-2-yl)-carbamic acid methyl ester affords the product as off-white solid in 93% yield. MS: m/e=430 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06963000B2 |
| 출처 데이터셋 | uspto-grants-2005_11 |
| ORD ID | ord-9c0ac871a8464558be98b32d0739b430 |
| 출처 메모 | uspto-grants-2005_11 |