Oxalyl chloride → tert-Butyl 4-(Chlorocarbonyl)piperidine-1-carboxylate

반응식

[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([OH:16])=O)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].C(Cl)(=O)C([Cl:20])=O>>[C:4]([O:3][C:1]([N:8]1[CH2:13][CH2:12][CH:11]([C:14]([Cl:20])=[O:16])[CH2:10][CH2:9]1)=[O:2])([CH3:7])([CH3:6])[CH3:5]

참가 물질

반응물 2

HCID 65578Oxalyl chloride

HCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid

생성물 1

HCID 21906247tert-Butyl 4-(Chlorocarbonyl)piperidine-1-carboxylate

실험 절차

1-Boc-piperidine-4-carboxylic acid (4.4 g, 19.2 mmol) in oxalyl chloride (50 mL) was heated at reflux for 3 h and then concentrated and dried in vacuo to give the acid chloride, 4-chlorocarbonyl-piperidine-1-carboxylic acid tert-butyl ester.

후처리

temperatureat reflux for 3 h
concentrationconcentrated
customdried in vacuo

출처 및 근거

ORD 기록: ord-5221828bb8a54b578b8bd23339753922
출처 데이터셋: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06964956B2

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