HCID 12732179, 화합물 → HCID 23401143, 화합물

반응식

[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]3[CH:18]=[C:19]([C:21]([OH:23])=O)[S:20][C:13]=13)=[CH:6][CH:5]=2.[NH:24]1[CH2:28][CH2:27][CH2:26][C@H:25]1[C:29]([OH:32])([CH3:31])[CH3:30]>>[OH:32][C:29]([C@@H:25]1[CH2:26][CH2:27][CH2:28][N:24]1[C:21]([C:19]1[S:20][C:13]2[C:14](=[N:15][CH:16]=[CH:17][C:12]=2[NH:11][C:7]2[CH:6]=[C:5]3[C:4](=[CH:9][CH:8]=2)[NH:3][C:2]([CH3:10])=[CH:1]3)[CH:18]=1)=[O:23])([CH3:31])[CH3:30]

참가 물질

반응물 2

HCID 12732179HCID 12732179, 화합물

HCID 22278637HCID 22278637, 화합물

생성물 1

HCID 23401143HCID 23401143, 화합물

실험 절차

The title compound was prepared from 7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridine-2-carboxylic acid and (S)-2-pyrrolidin-2-yl-propan-2-ol by a procedure analogous to Example 21B. MS: 435.3; HPLC Rf: 4.134 min.; HPLC purity 95%.

출처 및 근거

ORD 기록: ord-167b72bae02f4eb3803fc0eb8f2b6e13
출처 데이터셋: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06964961B2

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