(S)-4-(pyrrolidin-2-ylmethyl)morpholine → HCID 23401151, 화합물

반응식

[NH:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[CH2:6][N:7]1[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1.[CH3:13][C:14]1[NH:15][C:16]2[C:21]([CH:22]=1)=[CH:20][C:19]([NH:23][C:24]1[CH:29]=[CH:28][N:27]=[C:26]3[CH:30]=[C:31]([C:33](O)=[O:34])[S:32][C:25]=13)=[CH:18][CH:17]=2>>[CH3:13][C:14]1[NH:15][C:16]2[C:21]([CH:22]=1)=[CH:20][C:19]([NH:23][C:24]1[CH:29]=[CH:28][N:27]=[C:26]3[CH:30]=[C:31]([C:33]([N:1]4[CH2:5][CH2:4][CH2:3][C@H:2]4[CH2:6][N:7]4[CH2:8][CH2:9][O:10][CH2:11][CH2:12]4)=[O:34])[S:32][C:25]=13)=[CH:18][CH:17]=2

참가 물질

반응물 2

HCID 7141612(S)-4-(pyrrolidin-2-ylmethyl)morpholine

HCID 22278637HCID 22278637, 화합물

생성물 1

HCID 23401151HCID 23401151, 화합물

실험 절차

The title compound was prepared from (S)-4-pyrrolidin-2-ylmethyl-morpholine and 7-(2-methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridine-2-carboxylic acid by a procedure analogous to Example 21B. MS: 476.3 (MH+); HPLC Rf: 5.378 min.; HPLC purity: 92%.

출처 및 근거

ORD 기록: ord-607041c521fb476daf9c356e65edf0d5
출처 데이터셋: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06964961B2

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