4-(4-Trifluoromethylphenyl)benzylchloride → [2-Methyl-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid

반응식

Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.C[O:20][C:21](=[O:32])[CH2:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([SH:30])=[CH:26][C:25]=1[CH3:31]>>[CH3:31][C:25]1[CH:26]=[C:27]([S:30][CH2:2][C:3]2[CH:8]=[CH:7][C:6]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)=[CH:5][CH:4]=2)[CH:28]=[CH:29][C:24]=1[O:23][CH2:22][C:21]([OH:32])=[O:20]

참가 물질

반응물 2

HCID 114599214-(4-Trifluoromethylphenyl)benzylchloride

HCID 20770797Methyl (2-methyl-4-sulfanylphenoxy)acetate

생성물 1

HCID 22280134[2-Methyl-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid

실험 절차

The title compound was prepared in the manner analogous to Example 1F using 3B and 2C. MS m/z 447 (M+1).

출처 및 근거

ORD 기록: ord-dbaef31f0ad749c7bfa1e2a8f59be4f8
출처 데이터셋: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06964983B2

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