5-Bromo-2,4-dimethoxybenzaldehyde → 2,4-Dimethoxy-5-pyrimidin-5-yl-benzaldehyde

HRID 10637

반응식

HRID 10637 반응식
Br[C:2]1[C:3]([O:12][CH3:13])=[CH:4][C:5]([O:10][CH3:11])=[C:6]([CH:9]=1)[CH:7]=[O:8].[N:14]1[CH:19]=[C:18](B(O)O)[CH:17]=[N:16][CH:15]=1>>[CH3:11][O:10][C:5]1[CH:4]=[C:3]([O:12][CH3:13])[C:2]([C:18]2[CH:19]=[N:14][CH:15]=[N:16][CH:17]=2)=[CH:9][C:6]=1[CH:7]=[O:8]

참가 물질

3

반응물 2

HCID 6683465-Bromo-2,4-dimethoxybenzaldehydeHCID 2795193(Pyrimidin-5-yl)boronic acid

생성물 1

HCID 219809892,4-Dimethoxy-5-pyrimidin-5-yl-benzaldehyde수율 98%

실험 절차

Ex-31A: 2,4-Dimethoxy-5-pyrimidin-5-yl-benzaldehyde was prepared from 5-bromo-2,4-dimethoxybenzaldehyde and pyrimidine-5-boronic acid in a similar manner as described in Ex-3A, 98% yield. 1H-NMR (CDCl3) δ 10.37 (s, 1H), 9.15 (s, 1H), 8.87 (s, 2H) 7.86 (s, 1H), 6.57 (s, 1H), 4.03 (s, 3H), 3.96 (s, 3H).

출처 및 근거

ORD 기록
ord-a1360300cdb744508e0514350ce69833
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094801B2

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