(7-Mercapto-indan-4-yloxy)-acetic Acid Methyl Ester → [7-(4'-Trifluoromethyl-biphenyl-3-ylmethylsulfanyl)-indan-4-yloxy]-acetic Acid

반응식

C[O:2][C:3](=[O:16])[CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:12]([SH:15])=[C:11]2[C:7]=1[CH2:8][CH2:9][CH2:10]2.Cl[CH2:18][C:19]1[CH:20]=[C:21]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)[CH:22]=[CH:23][CH:24]=1>>[F:32][C:31]([F:33])([F:34])[C:28]1[CH:29]=[CH:30][C:25]([C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([CH2:18][S:15][C:12]3[CH:13]=[CH:14][C:6]([O:5][CH2:4][C:3]([OH:2])=[O:16])=[C:7]4[C:11]=3[CH2:10][CH2:9][CH2:8]4)[CH:20]=2)=[CH:26][CH:27]=1

참가 물질

반응물 2

HCID 20770872(7-Mercapto-indan-4-yloxy)-acetic Acid Methyl Ester

HCID 222801383-(4-Trifluoromethylphenyl)-benzyl chloride

생성물 1

HCID 22280056[7-(4'-Trifluoromethyl-biphenyl-3-ylmethylsulfanyl)-indan-4-yloxy]-acetic Acid

실험 절차

The title compound was prepared in the manner analogous to Example 1F using 12C and 48B. MS m/z 473 (M+1).

출처 및 근거

ORD 기록: ord-2f9c425e45be4769ab09b83637023400
출처 데이터셋: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06964983B2

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