3-(Chloromethyl)-5-(4-chlorophenyl)-1,2-oxazole → {4-[5-(4-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic Acid

반응식

Cl[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[O:5][N:4]=1.C[O:16][C:17](=[O:28])[CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([SH:26])=[CH:22][C:21]=1[CH3:27]>>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2[O:5][N:4]=[C:3]([CH2:2][S:26][C:23]3[CH:24]=[CH:25][C:20]([O:19][CH2:18][C:17]([OH:28])=[O:16])=[C:21]([CH3:27])[CH:22]=3)[CH:7]=2)=[CH:9][CH:10]=1

참가 물질

반응물 2

HCID 14811003-(Chloromethyl)-5-(4-chlorophenyl)-1,2-oxazole

HCID 20770797Methyl (2-methyl-4-sulfanylphenoxy)acetate

생성물 1

HCID 22280198{4-[5-(4-Chloro-phenyl)-isoxazol-3-ylmethylsulfanyl]-2-methyl-phenoxy}-acetic Acid

실험 절차

The title compound was prepared in the manner analogous to Example 1F using 3-chloromethyl-5-(4-chloro-phenyl)-isoxazole and 2C. mp 79-80° C.; MS m/z 404 (M+1).

출처 및 근거

ORD 기록: ord-170439d54b2a4ee89197c31115d71d20
출처 데이터셋: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06964983B2

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