Allyl bromide → 3-Bromo-4-fluorophenyl allyl ether

HRID 1063846

반응식

HRID 1063846 반응식
[Br:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8].[CH2:10](Br)[CH:11]=[CH2:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:12]([O:9][C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Br:1])[CH:3]=1)[CH:11]=[CH2:10]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 27833813-Bromo-4-Fluorophenol

생성물 1

HCID 221447733-Bromo-4-fluorophenyl allyl ether수율 61%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 0.65 gm (3.43 mMol) 3-bromo-4-fluorophenol, 0.60 mL (6.86 mMol) allyl bromide, and 0.71 gm (5.15 mMol) potassium carbonate in 6 mL acetone was stirred at reflux for 13 hours. The reaction mixture was concentrated under reduced pressure and the residue subjected to silica gel chromatography, eluting with hexane. Fractions containing product were combined and concentrated under reduced pressure to provide 61% of the desired compound.

후처리

  1. temperatureat reflux for 13 hours
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. washeluting with hexane
  4. additionFractions containing product
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-43e0605e74b84098bd445cb921c3dbab
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06967201B1

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