4-[4-(4-Chloro-phenyl)-3-oxo-5-pyridin-4-yl-pyrazolidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester → HCID 69357048, 화합물

HRID 1064075노트

반응식

HRID 1064075 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH:18]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)[CH:17]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)[C:16](=[O:32])[NH:15]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:18]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[C:17]([C:25]3[CH:26]=[CH:27][C:28]([Cl:31])=[CH:29][CH:30]=3)[C:16](=[O:32])[NH:15]2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 693560934-[4-(4-Chloro-phenyl)-3-oxo-5-pyridin-4-yl-pyrazolidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 69357048HCID 69357048, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

To a solution of 4-[4-(4-Chloro-phenyl)-3-oxo-5-pyridin-4-yl-pyrazolidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester 0.42 gin ethanol 25 mL was added palladium on carbon 0.02 g. the reaction was heated to 50° C. for 48 hours. The reaction was cooled to room temperature, filtered and concentrated. Purification by flash chromatography gave the title compound as colorless oil. MS (ES+): 455 (M+H)+; (ES−): 453 (M−H).

후처리

  1. temperatureThe reaction was cooled to room temperature
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customPurification by flash chromatography

출처 및 근거

ORD 기록
ord-c3d1aec9e00140e08e92b4d793e7aae9
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06967254B2

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