HCID 22277996, 화합물 → HCID 9975019, 화합물
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH:13]([C:14]3[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=3)[N:12]([CH:20]([CH3:22])[CH3:21])[NH:11][C:10]2=[O:23])[CH:5]=[CH:6][C:7]=1[Cl:8].[Br-].[Br-].[Br-].C1([N+](CC)(CC)CC)C=CC=CC=1.C1([N+](CC)(CC)CC)C=CC=CC=1.C1([N+](CC)(CC)CC)C=CC=CC=1>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10](=[O:23])[NH:11][N:12]([CH:20]([CH3:21])[CH3:22])[C:13]=2[C:14]2[CH:15]=[CH:16][N:17]=[CH:18][CH:19]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]참가 물질
4
실험 절차
The solution of 4-(3,4-Dichloro-phenyl)-1-isopropyl-5-pyridin-4-yl-pyrazolidin-3-one 90 mg in dichloromethane 10 mL was treated with phenyltriethylammonium tribromide 0.1 g at room temperature, The reaction mixture was stirred at room temperature for 15 h. The reaction was quenched with sat. Na2SO3 25 mL at 0° C. The reaction mixture was extracted with dichloromethane, 3×50 mL. The combined organic phase was washed with brine, dried over anhydrous Na2SO4. After purification by flash chromatography, the title compound was obtained as light yellow solid 45 mg. MS (ES+): 348 (M+H)+.