5-(3-Bromo-4-fluorophenyl)-3-(4-methoxyphenyl)-[1,2,4]triazine → HCID 10248930, 화합물

HRID 1064270

반응식

HRID 1064270 반응식
Br[C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[N:12]=[N:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[F:8].[F:23][C:24]1[CH:25]=[N:26][CH:27]=[CH:28][C:29]=1[Sn](CCCC)(CCCC)CCCC>>[F:8][C:7]1[CH:6]=[CH:5][C:4]([C:9]2[N:10]=[C:11]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)[N:12]=[N:13][CH:14]=2)=[CH:3][C:2]=1[C:29]1[CH:28]=[CH:27][N:26]=[CH:25][C:24]=1[F:23]

참가 물질

3

반응물 2

HCID 99985945-(3-Bromo-4-fluorophenyl)-3-(4-methoxyphenyl)-[1,2,4]triazineHCID 222736013-Fluoro-4-(tributylstannyl)pyridine

생성물 1

HCID 10248930HCID 10248930, 화합물

실험 절차

5-(3-Bromo-4-fluorophenyl)-3-(4-methoxyphenyl)-[1,2,4]triazine (from Example 9 below) (150 mg, 0.42 mmol) was coupled to 3-fluoro-4-tributylstannylpyridine (170 mg, 0.43 mmol) using the method of Example 6 to give 5-[4-fluoro-3-(3-fluoro-pyridin-4-yl)phenyl]-3-(4-methoxyphenyl)-[1,2,4]triazine, crystallised from hot toluene (70 mg): δH (400 MHz, d6-DMSO) 3.88 (3H, s), 7.16 (2H, d, J 8.9 Hz), 7.69-7.77 (2H, m), 8.53 (2H, d, J 8.9 Hz), 8.63-8.67 (3H, m), 8.79 (1H, m), 10.05 (1H, s); m/z (ES+) 377.

출처 및 근거

ORD 기록
ord-d5e7c7ccd8764840b7e5168976c07c6d
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06969716B2

연결된 노트

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