3-Methylbenzoyl chloride → HCID 11156487, 화합물

HRID 1064353노트

반응식

HRID 1064353 반응식
[NH2:1][C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=1)[C:26](Cl)=[O:27]>N1C=CC=CC=1>[CH3:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=1)[C:26]([N:1]([C:26](=[O:27])[C:25]1[CH:29]=[CH:30][CH:31]=[C:23]([CH3:22])[CH:24]=1)[C:2]1[C:11]([C:12]#[N:13])=[C:10]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1)=[O:27]

참가 물질

4

반응물 2

HCID 743753-Methylbenzoyl chlorideHCID 112888282-Amino-3-cyano-4-benzylaminoquinoline

생성물 1

HCID 11156487HCID 11156487, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
0 °C

실험 절차

To the solution of 5 g of 2-amino-3-cyano-4-benzylaminoquinoline in 30 ml of pyridine 6 ml of 3-methylbenzoyl chloride are dropped, under stirring at 0° C. The reaction mixture is stirred at 80° C. for 8 hour, then it is poured onto 150 ml of ice-water. The precipitate is filtered off, washed twice with 40 ml of water. The resulting white crystalline material is recrystallized from 200 ml of ethanol to give 9.2 g of the title compound, mp.: 234° C.

후처리

  1. stirringThe reaction mixture is stirred at 80° C. for 8 hour
  2. filtrationThe precipitate is filtered off
  3. washwashed twice with 40 ml of water
  4. customThe resulting white crystalline material is recrystallized from 200 ml of ethanol

출처 및 근거

ORD 기록
ord-7067f38f0aae444aa9bfe75d70071d65
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06969723B2

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