참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4,5-Dichloro-2-nitroaniline | HCID 81149 | — |
| 반응물 | Piperazine-2-carboxylic acid | HCID 2723758 | — |
| 용매 | Cyclohexanol | HCID 7966 | — |
| 생성물 | 5-(3-Carboxypiperazin-1-yl)-4-chloro-2-nitroaniline | HCID 22272964 | 72.1% |
반응 단계
To a solution of 2.10 g of 4,5-dichloro-2-nitroaniline and 2.20 g of 2-piperazinecarboxylic acid in 20 ml of cyclohexanol, 4.80 g of sodium carbonate was added, followed by 14 hours' stirring at 150° C. After cooling the reaction liquid to room temperature, water was added and the system was washed with chloroform. The aqueous layer was purified with an ion-exchange resin (Diaion HP-20, Mitsubishi Kasei, eluent: methanol). Upon condensing the fraction containing the object product under reduced pressure, 2.20 g of the title compound was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06969712B2 |
|---|
| 출처 데이터셋 | uspto-grants-2005_11 |
|---|
| ORD ID | ord-5da0a42d4ec442708176b763c252be1f |
|---|
| 출처 메모 | uspto-grants-2005_11 |
|---|
