2,1,3-Benzoxadiazole-4-sulfonyl chloride → N-(2,1,3-benzoxadiazol-4-yl)-4-(1,4-diazepan-1-yl)-2-[(phenylsulfonyl)amino]benzenesulfonamide hydrochloride

HRID 1064476

반응식

HRID 1064476 반응식
N[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:4][C:3]=1[NH:22][S:23]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)(=[O:25])=[O:24].[N:32]1[O:33][N:34]=[C:35]2[C:40](S([Cl:44])(=O)=O)=[CH:39][CH:38]=[CH:37][C:36]=12>>[ClH:44].[N:32]1[O:33][N:34]=[C:35]2[C:40]([NH:22][S:23]([C:2]3[CH:7]=[CH:6][C:5]([N:8]4[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]4)=[CH:4][C:3]=3[NH:22][S:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)(=[O:25])=[O:24])(=[O:25])=[O:24])=[CH:39][CH:38]=[CH:37][C:36]=12

참가 물질

3

반응물 2

HCID 27354462,1,3-Benzoxadiazole-4-sulfonyl chlorideHCID 22272501N-(2-amino-5-(4-t-butyloxycarbonyl-1,4-diazepan-1-yl)-phenyl}benzenesulfonamide

생성물 1

HCID 22272516N-(2,1,3-benzoxadiazol-4-yl)-4-(1,4-diazepan-1-yl)-2-[(phenylsulfonyl)amino]benzenesulfonamide hydrochloride

실험 절차

N-(2,1,3-benzoxadiazol-4-yl)-4-(1,4-diazepan-1-yl)-2-[(phenylsulfonyl)amino]benzenesulfonamide hydrochloride was synthesized from N-{2-amino-5-(4-t-butyloxycarbonyl-1,4-diazepan-1-yl)-phenyl}benzenesulfonamide (0.072 g, 0.16 mmol) and 2,1,3-benzoxadiazol-4-yl sulfonyl chloride (0.072 g, 0.21 mmol) to give 38.0 mg of a light purple solid; M+1 537.2 Calcd 537.15; 1HNMR δ 8.21 (d, 1H), 7.80 (d, 1H), 7.68-7.46 (m, 6H), 6.92 (d, 1H), 6.49 (dd, 1H), 6.12 (d, 1H), 3.57 (app t, 2H), 3.34 (app t, 2H), 3.17 (app t, 2H), 3.11 (app t, 2H), 2.03-1.95 (m, 2H).

출처 및 근거

ORD 기록
ord-2cf800f8ac2a4aba949fd44b103adffd
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06969710B2

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