Chloroacetyl chloride → 2-Chloro-N-[2-(trifluoromethyl)phenyl]acetamide

반응식

[F:1][C:2]([F:11])([F:10])[C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5].[Cl:12][CH2:13][C:14](Cl)=[O:15]>>[Cl:12][CH2:13][C:14]([NH:5][C:4]1[CH:6]=[CH:7][CH:8]=[CH:9][C:3]=1[C:2]([F:10])([F:11])[F:1])=[O:15]

참가 물질

반응물 2

HCID 6577Chloroacetyl chloride

HCID 69222-(Trifluoromethyl)aniline

생성물 1

HCID 7372782-Chloro-N-[2-(trifluoromethyl)phenyl]acetamide

실험 절차

The subtitle compound was prepared from 2-trifluoromethylaniline(10.5 g) and chloroacetyl chloride (6.8 ml) by the method of Example 33 step (iii) as a white solid. Yield: 13.7 g

출처 및 근거

ORD 기록: ord-16e22f4069c6428a87bd5dd4cc422529
출처 데이터셋: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06969713B2

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