3-Cyanobenzene-1-sulfonyl chloride → cis-1-(3-Cyanobenzenesulphonyl)-2,6-dimethyl-4-phenylmethylpiperazine

HRID 1064596노트

반응식

HRID 1064596 반응식
[CH2:1]([N:8]1[CH2:13][C@@H:12]([CH3:14])[NH:11][C@@H:10]([CH3:15])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:16]([C:18]1[CH:19]=[C:20]([S:24](Cl)(=[O:26])=[O:25])[CH:21]=[CH:22][CH:23]=1)#[N:17]>N1C=CC=CC=1>[C:16]([C:18]1[CH:19]=[C:20]([S:24]([N:11]2[C@H:10]([CH3:15])[CH2:9][N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:13][C@@H:12]2[CH3:14])(=[O:26])=[O:25])[CH:21]=[CH:22][CH:23]=1)#[N:17]

참가 물질

4

반응물 2

HCID 28013603-Cyanobenzene-1-sulfonyl chlorideHCID 12197174(3r,5s)-1-Benzyl-3,5-dimethylpiperazine

생성물 1

HCID 69746861cis-1-(3-Cyanobenzenesulphonyl)-2,6-dimethyl-4-phenylmethylpiperazine

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of cis-4-benzyl-2,6-dimethylpiperazine (1 g), 4-N,N-dimethylaminopyridine(0.54 g), 3-cyanobenzenesulphonyl chloride (2.13 g) in pyridine (3 ml) were stirred at ambient temperature. After 1 h the mixture was partitioned between dichloromethane and water. The organic phase further washed with brine, collected, dried, (MgSO4) and solvent evaporated under reduced pressure to leave the subtitle compound as an orange gum. Yield: 1 g

후처리

  1. customAfter 1 h the mixture was partitioned between dichloromethane and water
  2. washThe organic phase further washed with brine
  3. customcollected
  4. customdried
  5. custom(MgSO4) and solvent evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-d447eb12e2d34832b0a79827c2d5c615
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06969713B2

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