2-chloro-N-(5-cyano-2-methylphenyl)acetamide → cis-2-[4-(3-Cyanobenzenesulphonyl)-3,5-dimethylpiperazin-1-yl]-n-(5-cyano-2-methylphenyl)acetamide

HRID 1064600노트

반응식

HRID 1064600 반응식
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][C:7]=1[CH3:14])=[O:4].[C:15]([C:17]1[CH:18]=[C:19]([S:23]([N:26]2[C@H:31]([CH3:32])[CH2:30][NH:29][CH2:28][C@@H:27]2[CH3:33])(=[O:25])=[O:24])[CH:20]=[CH:21][CH:22]=1)#[N:16]>>[C:15]([C:17]1[CH:18]=[C:19]([S:23]([N:26]2[C@@H:31]([CH3:32])[CH2:30][N:29]([CH2:2][C:3]([NH:5][C:6]3[CH:11]=[C:10]([C:12]#[N:13])[CH:9]=[CH:8][C:7]=3[CH3:14])=[O:4])[CH2:28][C@H:27]2[CH3:33])(=[O:24])=[O:25])[CH:20]=[CH:21][CH:22]=1)#[N:16]

참가 물질

3

반응물 2

HCID 222734112-chloro-N-(5-cyano-2-methylphenyl)acetamideHCID 69744750cis-1-(3-Cyanobenzenesulphonyl)-2,6-dimethylpiperazine

생성물 1

HCID 69745774cis-2-[4-(3-Cyanobenzenesulphonyl)-3,5-dimethylpiperazin-1-yl]-n-(5-cyano-2-methylphenyl)acetamide

실험 절차

The title compound was prepared from the product of step (i) (0.19 g) and the product from Example 80 step (ii) (0.2 g) by the method of Example 80 step (iii) as a white solid. Yield: 0.25 g

출처 및 근거

ORD 기록
ord-e70d5c1c298e4bc79df3685c4756b6e0
출처 데이터셋
uspto-grants-2005_11
특허 번호
US06969713B2

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