Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 4-Methylsulfonylacetophenone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Sodium Sulfite | HCID 24437 | — |
| 반응물 | 1-(4-(Methylthio)phenyl)ethan-1-one | HCID 74501 | — |
| 반응물 | Potassium Permanganate | HCID 516875 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Methylsulfonylacetophenone | HCID 82529 | — |
반응 단계
A solution of 152 g (0.96 mol) of KMnO4 in 3.5 1 of water is introduced into a mixture of 117.1 g (0.7 mol) of 4-(methylthio)acetophenone, prepared in Example 2c, and 292 ml of acetic acid. 2.3 l of water are added and the reaction temperature is allowed to return to room temperature. Saturated sodium sulfite solution is added dropwise until the solution is decolorized. This is left to stand overnight at room temperature. The solid obtained is filtered off, washed copiously with water and recrystallized from 95% ethanol to give 91.5 g of 4-(methylsulfonyl)acetophenone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723485 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-6d44d87ee23a4984ad13cff1877a23a4 |
| 출처 메모 | uspto-grants-1998_03 |