Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene → 2-Fluoro-N-phenylacetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene | HCID 241 | — |
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 2-Fluoroaniline | HCID 9584 | — |
| 생성물 | 2-Fluoro-N-phenylacetamide | HCID 9504 | — |
반응 단계
In benzene, 2-fluoroaniline was acetylated with acetic anhydride to obtain 2-fluoroacetanilide. This 2-fluoroacetanilide was held in glacial acetic acid at 43°-52° C. and an equivalent of chlorine gas was introduced, whereby 2-fluoro-4-chloroacetanilide was obtained. This product was deacetylated with hydrochloric acid and neutralized with sodium hydroxide to recover 2-fluoro-4-chloroaniline as an oil boiling at 64°-65° C./0.25 mmHg.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04328367 |
| 출처 데이터셋 | uspto-grants-1982_05 |
| ORD ID | ord-65735f6d54f24ea4b80fbe379973d5fc |
| 출처 메모 | uspto-grants-1982_05 |