Sodium Azide → 4-Acetylamino-5-chloro-2-methoxy-benzoyl azide

HRID 1065229

반응식

HRID 1065229 반응식
[C:1]([NH:4][C:5]1[C:13]([Cl:14])=[CH:12][C:8]([C:9](Cl)=[O:10])=[C:7]([O:15][CH3:16])[CH:6]=1)(=[O:3])[CH3:2].[N-:17]=[N+:18]=[N-:19].[Na+]>CC(C)=O>[C:1]([NH:4][C:5]1[C:13]([Cl:14])=[CH:12][C:8]([C:9]([N:17]=[N+:18]=[N-:19])=[O:10])=[C:7]([O:15][CH3:16])[CH:6]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 113799924-Acetamido-5-chloro-2-methoxybenzoyl chloride

생성물 1

HCID 205387424-Acetylamino-5-chloro-2-methoxy-benzoyl azide수율 209.7%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

An acetone solution of 4-acetylamino-5-chloro-2-methoxy-benzoyl chloride (e6) (2.0 g) was added to a stirred aqueous solution of sodium azide (2.0 g) and the suspension stirred at room temperature for 30 minutes. Extraction with ethyl acetate gave 4-acetylamino-5-chloro-2-methoxy-benzoyl azide (e7) (4.3 g) as a white crystalline solid on trituration under petrol, m.p. 135°-140°. [I.R.ν(N3)=2140 cm-1 and ν(C=O)=1645, 1705 cm-1 ]

후처리

  1. extractionExtraction with ethyl acetate

출처 및 근거

ORD 기록
ord-ef4d12771dba45edb8b93137f73420ac
출처 데이터셋
uspto-grants-1982_05
특허 번호
US04329344

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